Table 2.
Comparison of adherence to inhaled antibiotics and other medications in patients with cystic fibrosis
| Adherence measurements | Inhaled tobramycin | Dornase alpha | Azithromycin | Hypertonic saline | Airway clearance | Combined nebulized medicationsa | Enzymes | Vitamins |
|---|---|---|---|---|---|---|---|---|
| Eakin et al27 | ||||||||
| MPR, %b,c | 65 | 71 | 76 | 49 | NA | NA | NA | NA |
| Modi et al24,d | ||||||||
| Parent self-report, mean (SD) % | 85.0 (33.7) | 90.4 (25.9) | NA | NA | 74.4 (35.3) | 82.4 (31.6) | 89.5 (21.7) | 88.4 (27.6) |
| Child self-report, mean (SD) % | 83.3 (25.8) | 77.8 (44.1) | 66.9 (30.2) | 80.0 (36.9) | 90.0 (25.5) | 93.8 (17.1) | ||
| Daily phone diary, mean (SD) % | 36.1 (35.6) | 56.7 (45.8) | 51.1 (40.2) | 47.6 (41.0) | 27.4 (22.9) | 22.2 (34.2) |
Notes:
a
Included dornase alpha, inhaled tobramycin, albuterol;
b
adherence rates were presented graphically only;
c
there were no statistically significant differences in MPRs among the different medications;
d
differences in adherence rates among different medications were not evaluated statistically.
Abbreviations: MPR, medication possession ratio; NA, not applicable; SD, standard deviation.