Bmal1 (Global) |
Impaired gluconeogenesis, adipocyte differentiation, hyperlipidemia, glucose intolerance |
[34,42,60,117] |
Bmal1 (Liver specific) |
Fasting hypoglycemia, Impaired gluconeogenesis |
[42] |
Bmal1 (Pancreas using Pdx-1 Cre) |
Hyperglycemia, hypoinsulinemia, glucose intolerance |
[32–34] |
Bmal1 (β-cell specific using rip-Cre) |
Hyperglycemia, hypoinsulinemia, glucose intolerance |
[64] |
Clock |
Hypertriglyceridemia, hypercholesterolemia, hyperglycemia, hyperleptinemia |
[33,118] |
Per1&2 |
Glucose intolerance, altered lipid metabolism |
[42,119,120] |
Cry1&2 |
Glucose intolerance |
[121] |