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. 2016 Feb 18;10:757–765. doi: 10.2147/DDDT.S83848

Table 2.

Adverse events (grade ≥3) regardless of causality

Adverse events Topp et al50
(21 patients)
Topp et al53,54
(189 patients)
Peripheral blood
 Leukopenia 2 (9.5%) 15 (7.9%)
 Neutropenia 1 (4.8%) 30 (15.8%)
 Thrombopenia 1 (4.8%) 16 (8.4%)
Investigations
 ALT increased 1 (4.8%) 13 (6.8%)
 Ig decreased 5 (23.8%) ND
Infections
 Bacterial sepsis 1 (4.8%) 15 (7.9%)
 Bronchopneumonia 1 (4.8%) 17 (8.9%)
Neurologic events
 Syncope/convulsion 1 (4.8%) 2 (1%)
 Encephalopathy ND 6 (3.1%)
 Somnolence 1 (4.8%) 1 (<1%)
Metabolism disorders
 Hypokalemia 1 (4.8%) 13 (6.8%)
 Hypophosphatemia ND 10 (5.2%)

Abbreviations: ALT, alanine aminotransferase; Ig, immunoglobulin; ND, not done.