Table 1.
Patient characteristics
| Parameter | Long-term use of amiodarone prior to HTX (n=74) | No long-term use of amiodarone prior to HTX (n=456) | P-value |
|---|---|---|---|
| Recipient data | |||
| Age in years, mean ± SD | 53.1±8.1 | 51.5±10.8 | 0.1536 |
| Male sex, n (%) | 59 (79.7) | 353 (77.4) | 0.6567 |
| BMI, mean ± SD | 25.4±3.4 | 24.7±3.9 | 0.0854 |
| CAD, n (%) | 33 (44.6) | 189 (41.4) | 0.6108 |
| Arterial hypertension, n (%) | 42 (56.8) | 246 (53.9) | 0.6527 |
| Dyslipidemia, n (%) | 53 (71.6) | 286 (62.7) | 0.1390 |
| Diabetes mellitus, n (%) | 26 (35.1) | 156 (34.2) | 0.8765 |
| Renal insufficiency, n (%) | 52 (70.3) | 253 (55.5) | 0.0170* |
| Donor data | |||
| Age in years, mean ± SD | 40.4±13.2 | 39.5±13.3 | 0.6090 |
| Male sex, n (%) | 30 (40.5) | 207 (45.4) | 0.4360 |
| BMI, mean ± SD | 24.7±3.8 | 24.5±4.0 | 0.8131 |
| Principal diagnosis for HTX | |||
| Nonischemic CMP, n (%) | 48 (64.9) | 236 (51.7) | 0.0359* |
| Ischemic CMP, n (%) | 26 (35.1) | 155 (34.0) | 0.8474 |
| Valvular heart disease, n (%) | 0 (0.0) | 29 (6.4) | 0.0257* |
| Cardiac amyloidosis, n (%) | 0 (0.0) | 36 (7.9) | 0.0123* |
| Transplant sex mismatch | |||
| Mismatch, n (%) | 37 (50.0) | 192 (42.1) | 0.2035 |
| Donor (m) to recipient (f), n (%) | 4 (5.4) | 23 (5.0) | 0.8956 |
| Donor (f) to recipient (m), n (%) | 33 (44.6) | 169 (37.1) | 0.2158 |
| Perioperative data | |||
| Biatrial HTX, n (%) | 24 (32.4) | 137 (30.0) | 0.6786 |
| Bicaval HTX, n (%) | 11 (14.9) | 104 (22.8) | 0.1242 |
| Total orthotopic HTX, n (%) | 39 (52.7) | 215 (47.2) | 0.3751 |
| Ischemic time, min, mean ± SD | 207.4±67.5 | 212.1±64.9 | 0.5763 |
Note:
*
Statistically significant (P<0.05).
Abbreviations: HTX, heart transplantation; BMI, body mass index; CAD, coronary artery disease; CMP, cardiomyopathy; m, male; f, female; min, minutes; n, number; SD, standard deviation.