Figure 5.

Results from the TRYPHAENA trial comparing pCR rates by experimental treatment arm.

Note: Adapted from Schneeweiss A, Chia S, Hickish T, et al. Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: a randomized phase II cardiac safety study (TRYPHAENA). Ann Oncol. 2013;24(9):2278–2284, by permission of Oxford University Press.⁴⁴

Abbreviations: DTP, docetaxel, trastuzumab, and pertuzumab; DTP w/Carb, DTP with carboplatin; FEC w/DPT, fluorouracil, epirubicin, and cyclophosphamide with concurrent DTP; FEC -> DTP, FEC followed by DTP; pCR, pathological complete response.