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. Author manuscript; available in PMC: 2016 Feb 22.
Published in final edited form as: Twin Res Hum Genet. 2015 Jun 17;18(4):335–347. doi: 10.1017/thg.2015.36

Table 3.

ConsensusPathDB pathway results for all SNPs within genes nominally associated (p<0.01) with longitudinal alcohol consumption

Pathway P q Database Associated genes from GWAS in pathway
Mean Consumption
Neuronal System 2.5E-07 4.5E-04 Reactome SLC6A1; KCNC1; KCNC2; GABRG3; GABRG2; HSPA8; KCNG4; GRIK5; GLUL; SLC5A7; GABRB3; AP2B1; GRIP2; CALM2; CALM3; KCNG1; CACNB2; CACNA1B; CHRNB2; KCNMA1; PRKCB; GAD1; GRIA2; KCNS3; ABCC8; GABBR2; RIMS1; PLCB1; KCNJ11; GRIA1; VAMP1; KCNQ5; KCNAB1; RPS6KA2; KCNQ1; CHRNA4; KCNH8; KCNN1; CACNG4; CACNA2D3; CACNA2D1; KCNG3; KCNJ6; ADCY4; ACTN2; KCNH7; KCNMB2; KCNH1; KCNMB4; RASGRF2; GRIK1; HCN4; GJD2; GRIN2B; GNG7; CACNA1E; GNG2; SLC1A2; GRIP1; CACNG3; SYN2; SYN3; GNG8
Transmission across Chemical Synapses 3.7E-05 3.3E-02 Reactome SLC6A1; GABRG3; GABRG2; HSPA8; GLUL; SLC5A7; GABBR2; GAD1; GABRB3; CALM2; CALM3; CACNB2; CACNA1B; CHRNB2; CACNA1E; AP2B1; GRIA2; RIMS1; PLCB1; GRIA1; PRKCB; CHRNA4; CACNA2D3; CACNA2D1; ADCY4; ACTN2; RPS6KA2; GRIP2; KCNJ6; RASGRF2; SYN2; GRIK5; GRIN2B; GNG7; GNG2; SLC1A2; GRIK1; GRIP1; CACNG3; CACNG4; SYN3; GNG8
Celecoxib Pathway, Pharmacodynamics 1.9E-04 9.4E-02 PharmGKB PDK1; CACNA2D1; TBXAS1; PTGIR; CACNA1I; CACNB2; CACNA1B; KCNQ5; PTGER1; CACNA1E; KCNQ1; CTNNB1; CACNA1C; PTGS2; CACNA2D3; PLA2G4A; CACNA1S
Adherens junctions interactions 2.1E-04 9.4E-02 Reactome CDH11; CDH10; CDH13; CDH12; CTNNB1; PVRL2; CDH2; CDH6; CADM2; CDH4; CADM1
Nuclear Hormone Receptors 2.6E-04 9.4E-02 Signalink NR3C2; ESRRG; RARG; ESR1; HNF4A; HNF4G; NR4A1; NR2F1; RXRA; ESRRB; THRB; NR2C1; RORA; SMAD3; NR5A2
Developmental Trajectory
Developmental Biology 7.6E-05 8.1E-02 Reactome ITGA9; ROBO2; CDH15; NRP2; SCN5A; NRCAM; ITGA1; HRAS; DOCK1; PCSK6; TRIO; CTNNB1; MAP2K1; CSNK2A1P; MED6; DNM3; CHL1; STIP1; CACNA1G; PITPNA; NCAM1; SPTBN1; FURIN; NCOA3; PRNP; BOC; CACNB2; CACNA1C; CACNA1D; TLN1; MED15; SLIT1; SCN4A; CDH2; CDH4; EPHB2; LAMA1; ACVR2B; RAC2; SIAH1; CRMP1; UNC5A; SCN8A; COL9A1; PPARG; CLTA; COL5A1; ABLIM1; FES; ABLIM2; CTNNA2; KIAA1598; SEMA5A; ROBO1; PLXNA2; VAV2; ST8SIA2; ROCK2; PLXNA4; MEF2C; CDON; ANK3; NTN1; CNTN6; PAK7; SCN3B; MYO10
G Protein Signaling Pathways 1.1E-04 8.1E-02 Wikipathways GNAO1; HRAS; PDE1C; PRKCA; PRKCH; GNB5; PRKCE; GNB2; PRKCZ; PRKAR1A; ITPR1; AKAP1; KCNJ3; AKAP5; AKAP6; AKAP7; ADCY1; AKAP2; ADCY9; GNA14; GNGT2; PPP3CA; PDE4B; PDE4D
Axon guidance 1.3E-04 8.1E-02 Reactome ITGA9; ROBO2; SCN5A; NRCAM; ITGA1; HRAS; DOCK1; MAP2K1; CSNK2A1P; CNTN6; DNM3; CHL1; STIP1; TLN1; PITPNA; NCAM1; SPTBN1; CACNB2; CACNA1C; PRNP; CACNA1G; SLIT1; SCN4A; EPHB2; LAMA1; TRIO; RAC2; SIAH1; UNC5A; SCN8A; CACNA1D; CRMP1; COL5A1; ABLIM1; FES; ABLIM2; COL9A1; NRP2; KIAA1598; SEMA5A; ROBO1; NTN1; VAV2; ST8SIA2; ROCK2; PLXNA4; ANK3; PLXNA2; CLTA; PAK7; SCN3B; MYO10