Fig. 1. Crystal structures of metal-bound human S100A12 and amino acid sequence alignment of select S100A12 orthologues. (A) Structure of the Ca(ii)- and Cu(ii)-bound S100A12 homodimer (PDB ; 1ODB).24 Cu(ii) ions are shown as teal spheres, and Ca(ii) ions as yellow spheres. (B) View of the His3Asp motif of S100A12 taken from the structure of a Zn(ii)-bound form (PDB ; 2WCB).25 The Zn(ii) ion is shown as a brown sphere. (C) Structure of the Zn(ii)-bound S100A12 homodimer (PDB ; 2WCB).25 Zn(ii) ions are shown as brown spheres. (D) Sequence alignment of human (h), porcine (p), and bovine (b) S100A12. The secondary structural elements presented above the alignment are for the human form. The transition-metal binding residues are presented in orange.
