TABLE 3.

lncRNAs With Identified Functions in Development

Tissue	lncRNA	Function	References
Cardiovascular	Fendrr	Regulates cardiac development	Grote and Herrmann (2013); Grote et al. (2013)
	Braveheart	Regulates cardiovascular development	Klattenhoff et al. (2013)
	tie 1AS	Regulates TIE1 (tyrosine kinase with immunoglobulin-like and EGF-like domains 1) and vascular development	Li et al. (2010)
Hematopoietic	H19	Maintains hematopoietic stem cell quiescence	Venkatraman et al. (2013)
	lncRNA-αGT	Necessary for embryonic to adult alpha-globin switching	Arriaga-Canon et al. (2014)
	7 species	Controls terminal erythroid differentiation	Paralkar et al. (2014)
Musculoskeletal	SRA	Enhances myogenic differentiation and myogenic conversion of non-muscle cells	Hube et al. (2011)
	lincMD1	Enhances myoblast differentiation	Cesana et al. (2011)
	Dum	Regulates myoblast differentiation	Wang et al. (2015)
	MUNC	Induces myoblast differentiation	Mueller et al. (2015)
Neural	Six3OS	Regulates SIX3 (SIX homeobox 3) and retinal development	Rapicavoli et al. (2011)
	TUNAR	Regulates pluripotency and neural differentiation	Lin et al. (2014)
	Evf2	Represses DLX5 (distal-less homeobox 5) and controlling GABA circuitry	Berghoffet al. (2013)
	Pnky	Regulates neurogenesis from neural stem cells	Ramos et al. (2015)
Mammary	Pinc1	Regulates alveolar development	Shore et al. (2012)
	Zfas1	Regulates alveolar development	Askarian-Amiri et al. (2011)
Endoderm	DEANR1/LINC00261	Regulates endoderm differentiation	Jiang et al. (2015)
Adipose	HOTAIR	Regulates preadipocyte differentiation	Divoux et al. (2014)
	10 species	Regulates preadipocyte differentiation	Sun et al. (2013)