Table 3. Adjusted associations of improved eGFR slope, and declining eGFR slopes.
Model adjusted for age, race, gender, diabetes mellitus, hypertension, cardiovascular disease, hyperlipidemia, peripheral artery disease, cerebrovascular disease, chronic lung disease, hepatitis C, HIV, dementia, and initial eGFR. Reference group is patients with stable eGFR slope.
| Improved eGFR slope HR (CI) | Declining eGFR slope HR (CI) | |
|---|---|---|
| Age | 0.97 (0.97–0.97) | 1.01 (1.01–1.01) |
| Female gender | 0.82 (0.77–0.87) | 1.03 (0.97–1.10) |
| Black race | 1.12 (1.08–1.17) | 1.23 (1.19–1.28) |
| Other race | 1.01 (0.93–1.10) | 1.14 (1.05–1.24) |
| Cerebrovascular accident | 1.08 (0.96–1.22) | 1.37 (1.24–1.52) |
| Cardiovascular disease | 1.10 (1.08–1.13) | 1.46 (1.42–1.49) |
| Dementia | 1.41 (1.34–1.49) | 1.29 (1.23–1.35) |
| Diabetes mellitus | 1.15 (1.13–1.18) | 1.96 (1.92–2.01) |
| Hepatitis C | 1.40 (1.28–1.54) | 1.81 (1.66–1.98) |
| HIV | 1.25 (1.19–1.31) | 1.27 (1.22–1.33) |
| Hypertension | 1.10 (1.07–1.14) | 1.88 (1.82–1.95) |
| Hyperlipidemia | 0.97 (0.94–0.99) | 1.00 (0.97–1.02) |
| Chronic lung disease | 1.33 (1.29–1.36) | 1.31 (1.28–1.35) |
| Peripheral artery disease | 1.18 (1.12–1.24) | 1.68 (1.60–1.75) |
| Initial eGFR | 0.95 (0.95–0.96) | 1.02 (1.01–1.02) |
| Annual percentage weight change* | 0.96 (0.96–0.97) | 1.00 (1.00–1.01) |
| Microalbuminuria** | 0.94 (0.90–0.98) | 1.34 (1.28–1.39) |
| Albuminuria** | 0.76 (0.69–0.84) | 2.20 (2.05–2.37) |
*Model additionally adjusted for weight n = 185,508
** Model additionally adjusted for albuminuria n = 63,021