Table 6. Adjusted associations of trajectory phenotypes.
HIFNT = High Intercept and Fast Negative Trajectory includes trajectory F. HIPT = High Intercept Positive Trajectory and includes trajectory A and B; IIMNT = Intermediate Intercept Mild Negative Trajectory and includes trajectory C, and D; LIFNT = Low Intercept Fast Negative Trajectory and includes trajectory E and G; Model adjusted for age, race, gender, for age, race, gender, diabetes mellitus, hypertension, cardiovascular disease, hyperlipidemia, peripheral artery disease, cerebrovascular disease, chronic lung disease, hepatitis C, HIV, dementia, and eGFR at time of cohort entry (T0). Reference group is IIMNT.
| HIFNT OR (CI) | HIPT OR (CI) | IIMNT OR | LIFNT OR (CI) | |
|---|---|---|---|---|
| Age | 1.00 (0.99–1.00) | 0.97 (0.96–0.97) | 1 | 1.03 (1.02–1.03) |
| Female gender | 0.90 (0.70–1.17) | 0.92 (0.79–1.08) | 1 | 0.89 (0.77–1.03) |
| Black race | 1.13 (0.96–1.32) | 1.00 (0.90–1.11) | 1 | 1.26 (1.16–1.37) |
| Other race | 0.94 (0.63–1.41) | 0.96 (0.74–1.23) | 1 | 0.95 (0.78–1.17) |
| Cerebrovascular accident | 1.69 (1.08–2.62) | 1.01 (0.70–1.46) | 1 | 1.08 (0.84–1.38) |
| Cardiovascular disease | 1.10 (0.99–1.23) | 0.98 (0.91–1.06) | 1 | 1.22 (1.16–1.29) |
| Dementia | 1.18 (0.95–1.46) | 1.21 (1.04–1.40) | 1 | 0.87 (0.77–0.98) |
| Diabetes mellitus | 1.58 (1.42–1.76) | 1.07 (0.99–1.15) | 1 | 1.59 (1.51–1.67) |
| Hepatitis C | 1.26 (0.91–1.74) | 1.16 (0.93–1.45) | 1 | 1.21 (0.99–1.48) |
| HIV | 1.37 (1.14–1.65) | 1.20 (1.06–1.36) | 1 | 0.92 (0.83–1.02) |
| Hypertension | 1.22 (1.04–1.43) | 1.02 (0.93–1.12) | 1 | 1.50 (1.38–1.63) |
| Hyperlipidemia | 0.95 (0.84–1.08) | 0.91 (0.84–0.98) | 1 | 0.95 (0.89–1.00) |
| Chronic lung disease | 1.01 (0.95–1.21) | 1.26 (1.16–1.36) | 1 | 1.01 (0.95–1.07) |
| Peripheral artery disease | 1.32 (1.07–1.64) | 1.20 (1.02–1.40) | 1 | 1.23 (1.10–1.37) |
| T0 eGFR | 1.19 (1.18–1.19) | 1.16 (1.15–1.16) | 1 | 0.90 (0.90–0.90) |
| Annual percentage weight change * | 0.98 (0.97–1.00) | 0.99 (0.98–1.00) | 1 | 1.00 (0.99–1.00) |
| Microalbuminuria** | 1.41 (1.17–1.71) | 0.89 (0.78–1.03) | 1 | 1.57 (1.43–1.73) |
| Albuminuria** | 2.65 (1.82–3.86) | 0.76 (0.52–1.09) | 1 | 4.33 (3.55–5.27) |
*Model additionally adjusted for weight n = 38,997
** Model additionally adjusted for albuminuria n = 12,736