Table 2.
a: Results of 24 HIV-infected participants with discordant point-of-care HIV test results | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Last neg HIV test |
OraQuick OF |
OraQuick FS |
Uni-Gold | INSTI | Determine | 3rd or 4th gen EIA1 |
Western blot band pattern | HIV RNA (copies/mL) |
|||
Ag | Ab | ||||||||||
1 | 2 mo | — | — | — | ND | + | — | 3rd | — | Negative | 5.8 million |
2 | 4 yr | + | + | — | ND | ND | 3rd | + | 24, 31, 40, 55, 120 | 141,000 | |
3 | 2 yr | — | + | + | ND | ND | 3rd | + | 24, 31, 40, 55, 160 | 128,000 | |
4 | 2 yr | — | + | + | ND | ND | 3rd | + | 18, 24, 31, 40, 51, 55, 120, 160 | 25,000 | |
5 | NA | — | — | + | ND | ND | 3rd | + | 24, 51, 55, 160 | 12.8 million | |
6 | NA | — | — | + | ND | — | + | 3rd | + | 24, 40, 55, 160 | 21,000 |
7 | 1 yr | — | + | — | ND | — | + | 4th | Ab+ | 24, 51, 55 | 719,000 |
8 | 1 yr | — | + | + | ND | — | + | 4th | Ab+ | 24, 31, 55, 160 | 436,000 |
9 | 6 mo | — | + | + | ND | — | + | 4th | Ab+ | 24, 55, 160 | 33,000 |
10 | 2 mo | — | + | + | ND | — | + | 4th | Ab+ | 24, 55, 160 | 9000 |
11 | 3 mo | — | + | + | ND | — | + | 4th | Ab+ | 18, 24, 55, 160 | 32,000 |
12 | 2 mo | — | + | + | ND | — | + | 4th | Ab+ | 24, 160 | 94,000 |
13 | 2 mo | — | — | + | ND | — | + | 3rd | + | 18, 24, 31, 41, 51, 55, 65, 120, 160 | ND |
14 | 2 yr | — | — | + | ND | — | + | 3rd | + | 18, 24, 31, 40, 51, 55, 65, 120, 160 | ND |
15 | 4 mo | — | — | ND | + | — | + | 3rd | + | 24, 55, 160 | ND |
16 | 3 mo | — | — | ND | + | — | + | 3rd | + | 24, 51, 55, 160 | 347,000 |
17 | 7 mo | — | — | ND | + | — | + | 3rd | + | 18, 24, 65, 160 | 110,000 |
18 | 5 mo | — | — | ND | + | — | + | 3rd | + | 24, 51, 55, 160 | 62,000 |
19 | 4 mo | — | + | ND | + | — | + | 3rd | + | 18, 24, 31, 41, 51, 55, 65, 120, 160 | 7000 |
20 | 8 mo | — | + | ND | + | — | + | 4th | Ab+ | 24, 51, 55, 65, 120, 160 | 70,000 |
21 | NA | — | + | ND | + | — | + | 4th | Ab+ | 24, 55, 160 | 7000 |
22 | 2 mo | — | + | ND | + | — | + | 4th | Ab+ | Negative | 323,000 |
23 | 2 mo | — | + | ND | + | — | + | 4th | Ab+ | 160 | 316,000 |
24 | NA | — | — | ND | + | — | + | 4th | Ag+ | 24 | 4.4 million |
b: Results of 16 HIV-infected participants with antibody-negative/NAAT-Positive or POC-negative/EIA-positive HIV test results1 | |||||||||||
Last neg HIV test |
OraQuick OF |
OraQuick FS |
Uni-Gold | INSTI | Determine | 3rd or 4th gen EIA2 |
Western blot band pattern | HIV RNA (copies/mL) |
|||
Ag | Ab | ||||||||||
1 | 7 mo | — | — | — | ND | — | — | 3rd | + | Negative | 9.0 million |
2 | 8 mo | — | — | — | ND | — | — | 3rd | + | Negative | 587,000 |
3 | 5 mo | — | — | — | ND | — | — | 3rd | + | 18, 41, 51 | ND |
4 | 8 mo | — | — | NA | NA | — | — | 3rd | + | Negative | 5.8 million |
5 | NA | — | — | — | ND | ND | 3rd | + | NA | NA | |
6 | 2 mo | — | — | ND | — | — | — | 3rd | + | Negative | 8.5 million |
7 | 6 mo | — | — | — | ND | ND | 3rd | — | ND | 5.4 million | |
8 | 1 yr | — | — | — | ND | ND | 3rd | — | ND | >10 million | |
9 | 3 mo | — | — | — | ND | ND | 3rd | — | ND | 59,000 | |
10 | 1.5 mo | — | — | — | ND | ND | 3rd | — | ND | >10 million | |
11 | 2 yr | — | — | — | ND | ND | 3rd | — | ND | 306,000 | |
12 | 2 mo | — | — | — | ND | — | — | 3rd | — | ND | 25,000 |
13 | 3 mo | — | — | ND | — | — | — | 3rd | — | ND | 8,000 |
14 | 4 mo | — | — | ND | — | — | — | 3rd | — | ND | 1.1 million |
15 | NA | — | — | — | ND | — | — | 4th | Ag+ | negative | 33,000 |
16 | NA | — | — | ND | — | — | — | 4th | Ag+ | negative | 72,000 |
OF: oral fluids; FS: fingerstick; Ag: antigen; Ab: antibody; EIA: enzyme immunoassay; ND: not done; NA: not available
Results from participants #1–12 were previously reported [Stekler, J Clin Virol, 2013]
The ARCHITECT assay was considered to be reactive for antibody if the Multispot HIV-1/HIV-2 Rapid Test, performed for confirmatory testing, was reactive. It was considered to be reactive for p24 antigen if the Multispot was non-reactive.
The participant with acute HIV infection who had a reactive Determine Combo is shown as #1 in Table 2a.
The ARCHITECT assay was considered to be reactive for p24 antigen if the Multispot was non-reactive.