Table 1. Ex vivo brain concentration of [125I]8D3-F(ab′)2-h158 at 72 h post injection.
% Injected activity dose per gram brain tissue |
Kp
(brain-to-blood concentration ratio) |
|||
---|---|---|---|---|
Age (months) | Tg-ArcSwe | WT | Tg-ArcSwe | WT |
4 | 0.03±0.01 | 0.02±0.01 | 0.10±0.01 | 0.09±0.02 |
12 | 0.07±0.03*** | 0.02±0.00 | 0.28±0.08*** | 0.09±0.02 |
>18 | 0.14±0.04*** | 0.02±0.00 | 0.44±0.10*** | 0.06±0.01 |
All values are means±s.d. ***P<0.001 comparison between tg-ArcSwe and WT mice by two-way analysis of variance followed by Bonferroni's post hoc test.