Table 2. Radioligand concentrations and injected doses.
| Radioligand | Labelling reaction yield (%) | Specific activity (MBq nmol−1) | Injected radioactivity (MBq) | Number of studied mice (tg/WT) |
|---|---|---|---|---|
| [125I]F(ab′)2 | 78±10 | 130±36 | 4.9±1.3 | 3/3 |
| [125I]8D3 | 54±12 | 55±10 | 2.4±1.1 | 4/7 |
| [125I]Fab-8D3 | 55±5.4 | 25±4.8 | 4.6±0.1 | 2/4 |
| [125I]8D3-F(ab′)2-h158 | 70±12 | 136±24 | 1.4±0.8 | 29/26 |
| [124I]8D3-F(ab′)2-h158 | 74±3.7 | 218±29 | 14.5±1.6 | 21*/13 |
| [125I]8D3-F(ab′)2-Synagis | 43 | 116 | 0.8±0.2 | 2/4 |
| [124I]8D3-F(ab′)2-Synagis | 62 | 193 | 13.3±0.3 | 2/1 |
| Radio-chemical purity (%) | Specific Activity (MBq nmol−1) | Injected radioactivity (MBq) | Number of studied mice (tg/WT) | |
| [11C]PIB | >95 | 13±18 | 8.5±4.4 | 10/4 |
tg, transgenic; WT, wild type.
Values are means±s.d.
*Including (Thy-1)-h[A30P] α-synuclein transgenic mice (n=4).