Table 3. Hypothetical tests with 10% of patients in the HR group for different sensitivity values, showing agranulocytosis risks the LR group (1-NPV), in the HR group (PPV) and specificity of the test.
| Sensitivity | P(A|LR) (1-NPV) | P(A|HR) (PPV) | Specificity |
|---|---|---|---|
| 0.200 | 0.0071 | 0.016 | 0.901 |
| 0.400 | 0.0053 | 0.032 | 0.902 |
| 0.600 | 0.0036 | 0.048 | 0.904 |
| 0.800 | 0.0018 | 0.064 | 0.906 |
| 1 | 0 | 0.080 | 0.907 |
Abbreviations: HR, high risk; LR, low risk; NPV, negative predictive value; PPV, positive predictive value.