Fig. 4.

Deferoxamine and chlorzoxazone ameliorate neurodegeneration in flies expressing a mutant HTT fragment. Drosophila expressing HTT93Q exon 1 pan-neuronally were exposed to either deferoxamine or chlorzoxazone in their food at the concentrations shown for 7 days. Rhabdomeres were scored via the pseudopupil assay. a Representative images of control and treated Drosophila rhabdomeres. b Both deferoxamine and chlorzoxazone significantly increased rhabdomere number in HTT93Q exon 1-expressing flies. Data represent the mean rhabdomere count per ommatidium ± SEM (N = 12). **P < 0.01, ***P < 0.001