Fig. 4.

Glycogen degradation pathways. Glycogen can be degraded via two pathways. Glycogen phoshorylase and glycogen debranching enzyme produce glucose-1-phosphate (around 90 %) and free glucose (around 10 %) which converted to glucose-6-phosphate and enters glycolysis and TCA cycle. Autophagy-dependent glycogen degradation is very important in the newborns and produces free glucose via the lysosomal 1,4-α-glucosidase activity