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. 2016 Feb 22;11(2):e0149386. doi: 10.1371/journal.pone.0149386

Fig 2. Jujuboside B reduced vascular tension of endothelium-intact vascular rings depending on eNOS activity.

Fig 2

(A) Representative vascular tension trace showed that distilled water (served as Control) did not relax vascular rings preconditioned with PE. (B) Representative vascular tension trace showed that Jujuboside B relaxed vascular rings preconditioned with PE in a dose-dependent manner. (C) Dose-response curves showed that Jujuboside B significantly relaxed vascular rings preconditioned with PE in a dose-dependent manner. ** P < 0.01, n = 4. (D) Representative vascular tension trace showed that removing vascular endothelium significantly inhibited Jujuboside B-induced vasodilation in vascular rings preconditioned with PE. (E) Dose response curves showed that removing vascular endothelium significantly inhibited Jujuboside B-induced vasodilation. ** P <0.01, n = 4. (F) Representative vascular tension trace showed that L-NAME significantly inhibited Jujuboside B-induced vasodilation in endothelium-intact vascular rings preconditioned with PE. (G) Representative vascular tension trace showed that indometacin did not affect Jujuboside B-induced vasodilation in endothelium-intact vascular rings preconditioned with PE. (H) Dose response curves showed that L-NAME significantly inhibited Jujuboside B-induced vasodilation, while indometacin had no inhibitory effect. ** P <0.01, n = 4.