Fig 9. Jujuboside B reduced vascular tension involving endothelium dependent hyperpolarization through endothelial BK_Ca channels.

(A)Representative vascular tension trace showed that SNP reduced vascular tension of endothelium-intact vascular rings preconditioned with PE in a dose-dependent manner. (B) Representative vascular tension trace showed that iberiotoxin significantly inhibited SNP-induced vasodilation in endothelium-intact vascular rings. (C) Dose response curves showed that iberiotoxin significantly inhibited SNP-induced vasodilation, ** P < 0.01, n = 3. (D) Representative vascular tension trace showed that SNP significantly reduced vascular tension of endothelium-denuded vascular rings preconditioned with PE in a dose-dependent manner. (E) Representative vascular tension trace showed that iberiotoxin did not inhibited SNP-induced vasodilation in endothelium-denuded vascular rings. (F) Dose response curves showed that iberiotoxin did not affect SNP-induced vasodilation in endothelium-denuded vascular rings, n = 3. (G) Representative vascular tension trace showed that iberiotoxin significantly inhibited Jujuboside B-induced vasodilation in endothelium-intact vascular rings preconditioned with PE. (H) Dose response curves showed that iberiotoxin significantly inhibited Jujuboside B-induced vasodilation, ** P < 0.01, n = 4.