Table 3.
Iron homeostasis serum proteins profiles in SCD patients in the steady state and in controls.
| Proteins | SCD patients |
Controls |
p-valuec | ||||
|---|---|---|---|---|---|---|---|
| Mean ± SD | Subjects with values above the cut-offa, n (%) | Median/interquartile rangeb | Mean ± SD | Median/interquartile rangeb | Subjects with values above the cut-offa, n (%) | ||
| Transferrin (g/L) | 4.1 ± 1.5 | 16 (21.9) | – | 6.9 ± 3.1 | – | 46 (67.6) | <0.0001 |
| sTfR (μg/mL) | 5.9 ± 2.2 | 56 (76.7) | – | 1.8 ± 0.7 | – | 5 (6.8) | <0.0001 |
| Ferritin (ng/L) | 558.9 ± 434.7 | 48 (65.8) | 445.6/(174.8−933.3) | 44.0 ± 28.9 | 37.6/(24.3−54.5) | 0 | <0.0001 |
| sTfR index | 1.5 ± 0.3 | 25 (34.2) | – | 2.1 ± 0.9 | – | 58 (79.4) | <0.0001 |
| Hepcidin (ng/mL) | 231.6 ± 128.2 | 47 (64.4) | 215.2/(127.3−287.4) | 225.6 ± 135.1 | 192.9/(130.3−296.9) | 41 (56.2) | 0.6487 |
aCut-off values defined in Section “Materials and Methods.”
bMedian and interquartile range for non-normally distributed proteins ferritin and hepcidin.
cWilcoxon test, means comparisons.