Table 2. Associations between Polymorphisms and Antibody Responses against Blood-Stage Proteins of P. vivax.
| PvAMA-1 | PvDBP | PvMSP-119 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Model | Genotype | OR (95%CI)a | pb | OR (95%CI)a | pb | OR (95%CI)a | pb |
| BLYS | rs9514828 | Dominant | C/C | 1.00 | 0.04 | 1.00 | 0.39 | 1.00 | 0.01 |
| C/T–T/T | 1.68 (1.01–2.79) | 1.26 (0.74–2.14) | 2.01 (1.12–3.61) | ||||||
| Recessive | C/C–C/T | 1.00 | 0.22 | 1.00 | 0.80 | 1.00 | 0.83 | ||
| T/T | 1.91 (0.65–5.57) | 0.87 (0.30–2.51) | 0.89 (0.29–2.74) | ||||||
| Log-Additive | 0,1,2 | 1.59 (1.05–2.40) | 0.03 | 1.14 (0.74–1.74) | 0.56 | 1.47 (0.91–2.37) | 0.11 | ||
| CD86 | rs1129055 | Dominant | G/G | 1.00 | 0.85 | 1.00 | 0.45 | 1.00 | 0.22 |
| G/A–A/A | 0.95 (0.57–1.58) | 1.23 (0.72–2.11) | 0.70 (0.39–1.24) | ||||||
| Recessive | G/G–G/A | 1.00 | 0.61 | 1.00 | 0.17 | 1.00 | 0.31 | ||
| A/A | 1.32 (0.45–3.85) | 2.19 (0.69–6.96) | 1.84 (0.56–6.07) | ||||||
| Log-Additive | 0,1,2 | 1.01 (0.67–1.52) | 0.97 | 1.28 (0.83–1.97) | 0.26 | 0.88 (0.56–1.38) | 0.58 | ||
| CD40 | rs1883832 | Dominant | C/C | 1.00 | 0.36 | 1.00 | 0.03 | 1.00 | 0.31 |
| C/T–T/T | 0.77 (0.44–1.35) | 0.53 (0.30–0.94) | 0.73 (0.39–1.35) | ||||||
| Recessive | C/C–C/T | 1.00 | 0.66 | 1.00 | 0.21 | 1.00 | 0.92 | ||
| T/T | 1.35 (0.35–5.27) | 0.39 (0.09–1.66) | 1.09 (0.23–5.13) | ||||||
| Log-Additive | 0,1,2 | 0.87 (0.55–1.37) | 0.54 | 0.57 (0.35–0.92) | 0.02 | 0.81 (0.48–1.35) | 0.42 | ||
| CD40Lc | rs3092945 | Dominant | T/T | 1.00 | 0.63 | 1.00 | 0.36 | 1.00 | 0.70 |
| T/C–C/C | 1.24 (0.51–3.06) | 1.54 (0.61–3.88) | 0.83 (0.31–2.18) | ||||||
| Recessive | T/T–T/C | 1.00 | 0.70 | 1.00 | 0.60 | 1.00 | 0.92 | ||
| C/C | 1.46 (0.21–10.39) | 0.59 (0.09–4.03) | 0.89 (0.08–9.86) | ||||||
| Log-Additive | 0,1,2 | 1.21 (0.59–2.48) | 0.60 | 1.24 (0.58–2.64) | 0.58 | 0.86 (0.38–1.94) | 0.72 | ||
aOR stands for odd ratio and CI stands for confidence intervals.
bp values based on fitting logistic regression models adjusted for gender and current malaria infection. P values < 0.05 are in bold.
cGenotypes available only for women because the CD40L gene is located on chromosome X.