Table 3.

Clinical, radiographic and histopathological parameters and early CD remission 6 months after pituitary surgery – univariate analysis.

	Macroadenoma			Microadenoma			Total
n	Remission (%)	P value	n	Remission (%)	P value	n	Remission (%)	P value
Total	20	30.0		39	84.6		59	66.1
Tumour volume			0.141t						<0.001t
Microadenoma	–	–		39	84.6		39	84.6
Macro <2500 mm3	10	50.0		–	–		10	50.0
Macro ≥2500 mm3	10	10.0		–	–		10	10.0
Invasiveness			0.011			0.007			<0.001
Knosp 0–2 (macro-), pseudocapsule (micro-)	10	60.0		22	100.0		32	87.5
Knosp 3,4 (macro-), no pseudocapsule (micro-)	10	0.0		15	66.7		25	40.0
Ultrastructure			0.605			0.382			0.034
DGCA	13	38.5		25	88.0		38	71.7
SGCA	6	16.7		3	66.7		9	33.3
Ki-67			0.762t			0.559			0.079t
<3%	11	27.3		28	89.3		39	71.8
3–10%	6	50.0		6	83.3		12	66.7
>10%	3	0.0		0	–		3	0.0
p53			0.559t			0.552			0.650t
<5%	11	27.3		25	84.0		36	66.7
5–50%	5	20.0		7	100.0		12	66.7
>50%	4	50.0		0	–		4	50.0
Atypical adenoma			0.613			1.000			0.682
No	15	26.7		30	86.7		45	66.7
Yes	5	40.0		2	100.0		7	57.1
Mitoses per 10 HPF			1.000			1.000			0.594
≤2	18	33.3		32	87.5		50	68.0
>2	2	0.0		2	100.0		4	50.0

Subscript t denotes P value in a test for trend.