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. 2016 Jan 15;30(2):247–254. doi: 10.1038/eye.2015.264

Figure 1.

Figure 1

(a) Innervations of M1–M5 type pRGCs in the mouse brain as revealed by intravitreal delivery of AAV2 viral vectors containing lox.STOP.lox.mCherry into the retina of Opn4.Cre mice. (b) Images showing the morphology of pRGC subtypes of the mouse retina. M1, M2, and M3-type pRGCs are labelled using anti-melanopsin antibodies. M4 - and M5-type pRGCs are identified by expression of EYFP in Opn4.Cre.EYFP mice and the lack of detectable melanopsin labelling. (c) Examples of types III and II melanopsin responses recorded from the adult mouse retina using multiple electrode arrays, typical of M1 - and non-M1-type pRGCs, respectively. Black bars indicate duration of light pulse (30 s, 480 nm, 15.1 log photons/cm2/s). dLGN, dorsal lateral geniculate nucleus; GCL, ganglion cell layer; IGL, intergeniculate leaflet; INL, inner nuclear layer; IPL, inner plexiform layer; OFF, OFF layer of the inner plexiform layer; ON, ON layer of the inner plexiform layer; OPN, olivary pretectal nucleus; SCN, suprachiasmatic nucleus; vLGN, ventral lateral geniculate nucleus.