Table 2. Transcription factors predicted to bind the AT and G alleles of rs386770867.
Allele | Program | Transcription factor | Strand | Sequence (5′–3′) | Score |
---|---|---|---|---|---|
AT | TFSearch | SRY | − | TGAGTTT | 87.3 |
TFScan | HS$IL_06 | + | TTCC | — | |
HS$GMCSF_04 | + | CATTT | — | ||
HS$GG_12 | + | CTGTC | — | ||
+ | CTGTC | — | |||
G− | TFSearch | SRY | − | TGAGTTT | 87.3 |
TFScan | HS$GG_12 | + | CTGTC | — | |
+ | CTGTC | — | |||
MatInspector | v-Myb (Viral?) | − | CTGAACGGAGG | 0.915 |
Searches were performed using the programs TFSearch,9 TFScan10 and MatInspector.11 The polymorphism is shown in boldface in the transcription factor binding sequences. The score is as reported by the search program. No scores are reported by TFScan (indicated by a dash). For MatInspector, the matrix similarity score is given; a value of 1 indicates a perfect match. For TFSearch, a score of 100 indicates a perfect match.