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. 2016 Feb 23;6:21868. doi: 10.1038/srep21868

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(A) Release of sICAM and sVCAM in response to primary monocyte perfusion and adhesion. (B) Secretion of IL-1β, IL-6, TNFα and IL-10 in response to primary monocyte perfusion and adhesion. Liver organoids were untreated (dashed line) or stimulated with LPS (solid line), without monocyte perfusion (left from vertical dashed line) or with monocyte perfusion (right from vertical dashed line). (A,B) Statistical significance was calculated between untreated and LPS-treated liver organoids of identical time points and perfusion conditions (*p < 0.05, **p < 0.01, ***p < 0.001) using student’s t-test. Results of six independent experiments are shown.