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. 2016 Feb 23;6:21868. doi: 10.1038/srep21868

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Messenger RNA expression of cytokines (A), CYP3A11 (B) and MRP-2 (C). Enzyme activity of CYP3A family members using the model reaction ethylmorphine-N-demethylation (D,E) Serum concentrations of ASAT, ALAT and albumin. Statistically significance was calculated using one-way ANOVA with Dunn’s test for multiple testing correction (^#p < 0.05). (A–E) Five animals per time point were analyzed.