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. 2016 Feb 23;6:21973. doi: 10.1038/srep21973

Figure 5. In vitro analysis of HPβCD-treated OHCs.

Figure 5

(a) Time-lapse images of HPβCD-treated WT OHCs. Isolated OHCs from a WT-control mouse were treated with 1 mM HPβCD and observed under microscopy. OHCs rapidly shorten upon addition of HPβCD. Scale bars, 5 μm. (b) HPβCD treatment of an isolated OC from a WT mouse treated with 10 mM HPβCD. The initial image (t = 0, before the addition of HPβCD) is shown. Red asterisks (*) indicate cells that ruptured during the duration of time-lapse recording. (c) HPβCD treatment of an isolated OC from a prestin-KO mouse treated with 10 mM HPβCD. The initial image (t = 0, before the addition of HPβCD) is shown. Red asterisks (*) indicate cells that ruptured during the duration of time-lapse recording; white asterisks are OHCs that seem to have swollen but not ruptured.