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. 2016 Feb 23;6:21678. doi: 10.1038/srep21678

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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MCC tumor samples from 34 patients were analyzed by immunohistochemistry for expression of MICA and MICB. (a) Samples were classified as positive or negative. Representative negative and positive samples are depicted at 40× magnification, scale bars are 100 μm. The positive examples represent the strongest obtained signal with the respective antibody. (b) Tumor samples were stratified into 4 groups: Double positive for MICA and MICB (+/+, 14%, n = 7), only positive for MICA (+/−, 20%, n = 10), only positive for MICB (−/+, 12%, n = 6), or double negative (−/−, 54%, n = 27).