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. 2016 Feb 23;6:22066. doi: 10.1038/srep22066

Figure 6. Effects of Pygo2 knockdown by shRNAs on the recruitment of histone methyltransferase complex to the Wnt target genes promoters.

Figure 6

The core components of COMPASS-like complex, WDR5 and Ash2 on the promoters of Wnt/β-catenin pathway target genes in human brain glioma U251 (A,B) and U-87MG (D,E) cell lines were examined. The specific subunit of the MLL1/MLL2 histone methyltransferase (HMT) complex, menin (C,F), and specific subunits of SET-1 and MLL3/MLL4, CXXC1 (G,I) and NCOA6 (H,J), were also examined similarly. *P < 0.05 and **P < 0.01.