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. 2016 Feb 23;6:21931. doi: 10.1038/srep21931

Figure 1. IL-1β promotes seizure susceptibility after prolonged FS.

Figure 1

(A) Experimental protocols. (B) Representative EEG recorded in the hippocampus of an 8-day-old rat pup during prolonged FS. Top two panels: pre-ictal, ictal, post-ictal EEG and the enlargement of the rhythmic discharges. Third panel: hippocampal EEG recorded during hyperthermia in rat pretreated with pentobarbital (H-CON). (C) Seizure stages induced by MES in rats experienced simple or prolonged FS (three experiments; n = 7 in control group and n = 8 in other groups). (D) Seizure progression induced by KA in rats experienced prolonged FS (three experiments; n = 8 in each group). (E,F) Representative Western blots of IL-1β from hippocampi immediately after simple or prolonged FS (E), and at different times after prolonged FS (F), while GAPDH was used as loading control (Results represent two to three experiments). (G) Seizure stages induced by MES in rats treated with different doses of IL-1β on P8 (three experiments; n = 8 for control, n = 7 for other groups). (H) seizure progression induced by KA in rats treated with IL-1β on P8 (three experiments; n = 8 in each group; Two-way ANOVA with Bonferroni’s post hoc test). One-Way ANOVA with Turkey’s post-hoc test. **P < 0.01 and ***P < 0.001 compared to control. Error bars indicate S.E.M. S-FS, simple FS; P-FS, prolonged FS.