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. 2016 Feb 23;6:21931. doi: 10.1038/srep21931

Figure 2. IL-1Ra time-dependently prevents the enhanced seizure susceptibility after prolonged FS.

Figure 2

(A,B) Seizure stages induced by MES in rats delivered with different doses of IL-1Ra immediately after prolonged FS (A, three experiments; n = 8 in FS + IL-1Ra groups, n = 7 in control and FS groups), or treated with 100 ng IL-1Ra at different times after prolonged FS (B, three experiments; n = 7–8/group). (C) Seizure progression induced by KA with different treatments (n = 10 in control and FS groups, n = 9 in other groups; Two-way ANOVA with Bonferroni’s post hoc test). Latency to generalized seizures (D) and latency to abnormal EEG (E) in rats after KA injection (n = 10 in control and FS groups, n = 9 in other groups). (F) Representative EEG tracings from rats following KA injection. The arrow indicates the onset of electrographic seizure.**P < 0.01 and ***P < 0.001 compared to control. #P < 0.05, ###P < 0.001 compared to FS group, $$$P < 0.001 compared to FS + IL-1Ra group. One-Way ANOVA with Turkey’s post-hoc test. Error bars indicate S.E.M. H-CON, hyperthermia without seizures. N.S., not significant.