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. 2016 Feb 23;6:21931. doi: 10.1038/srep21931

Figure 3. The effect of IL-1β on seizure susceptibility after prolonged FS requires its receptor IL-1R1.

Figure 3

(A) Latency to the onset of FS, which is a reliable measure of susceptibility, in wild-type and IL-1R1−/− mice (three experiments; two-tailed Student’s t-test, n = 8/group). (B) Representative Western blots of IL-1β from hippocampi of IL-1R1−/− mice, while GAPDH was used as loading control. (C) Seizure threshold of MES-induced generalized seizures of wild-type and IL-1R1−/− mice after FS or IL-1β treatment (two to three experiments; n = 10 for control group, n = 9 for FS and IL-1β in wild-type mice, n = 8 for FS and IL-1β in IL-1R1−/− mice). Latency to KA-induced generalized seizures in wild-type (D) and IL-1R1−/− mice (E) after FS (two-tailed Student’s t-test, n = 8/group). (F) Representative EEG tracings of mice following KA injection. The arrow indicates the onset of electrographic seizure. **P < 0.01, ***P < 0.001compared to control group. One-Way ANOVA with Turkey’s post-hoc test for multiple groups. Error bars indicate S.E.M.