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. 2016 Feb 23;6:21931. doi: 10.1038/srep21931

Figure 5. CB1R mediates the effect of IL-1β on seizure susceptibility after prolonged FS.

Figure 5

(A,B) MES-induced seizure stages of rats treated with SR 141716 A (SR) after FS or IL-1β (three experiments; n = 8 in control group, n = 8 for other groups in A; n = 7 in FS group and n = 6 in other groups). (C) Threshold to the onset of MES-induced generalized seizures in mice transducted with CB1R-shRNA or scrambled shRNA lentivirus after prolonged FS or IL-1β injection (three experiments; n = 8/group). (D) Seizure threshold to the onset of MES-induced generalized seizures in wild-type and IL-1R1−/− mice treated with WIN 55,212-2 after prolonged FS or IL-1Ra after prolonged FS (three experiments; wild-type mice: n = 6–8/group). (E) Typical traces recorded in the CA1 pyramidal neurons of hippocampal slice from prolonged FS and age-matched control group (two-tailed Student’s t-test, n = 22 neurons/group). (F) Typical traces recorded in the CA1 pyramidal neurons of hippocampal slice from IL-1β and IL-1Ra treated group (two-tailed Student’s t-test, n = 25 neurons/group). *P < 0.05, and ***P < 0.001 compared to control group; ##P < 0.01, ###P < 0.001 compared to FS or IL-1β; $$P < 0.01 compared to FS + IL-1Ra group. One-Way ANOVA with Turkey’s post-hoc test. Error bars indicate S.E.M. N.S., not significant.