Table 1.

Effect of GABAergic chemicals in AD models.

Name	Type	Effect	Reference
Etazolate (EHT-0202)	GABAA receptor agonist	Protected neurons again Aβ-induced toxicity, increased the protein level of sAPPα, displayed anti-inflammation effect after traumatic brain injury and improved cognition in mice models.	Marcade et al. (2008); Drott et al. (2010); Vellas et al. (2011) and Siopi et al. (2008)
Muscimol	GABAA receptor agonist	Inhibited Aβ25–35-induced apoptotic death in neurons.	Lee et al. (2005)
Propofol	GABAA receptor agonist	Decreased Aβ generation and accelerated Aβ degradation, reduced the levels of Aβ40 and Aβ42 in aged mice brain. Improved cognitive function and attenuated caspase-3, caspase-9 activation in AD mice model.	Shao et al. (2014) and Zhang et al. (2014)
MRK-016, α5IA, α5IA-II	Inverse agonists of GABAA receptor α5 subunit	Improved cognition in animal models.	Dawson et al. (2006); Atack et al. (2009); Atack (2010) and Guerrini et al. (2013)
CGS9896	Inverse agonists of GABAA receptor α5 subunit	Enhanced the murine memory task.	Guerrini et al. (2009)
Ro-4938581, Ro-4882224	Inverse agonists of GABAA receptor α5 subunit	Reversed the scopolamine-induced impairment in working memory.	Knust et al. (2009)
SGS742 (CGP36742)	GABAB receptor antagonist	Improved attention and working memory in animal models and patients with mild cognitive impairment, increased the levels of NGF and BDNF in rats.	Getova and Bowery (2001); Froestl et al. (2004) and Helm et al. (2005)
CGP55845	GABAB receptor antagonist	Improved cognition in rat model.	Cryan and Kaupmann (2005) and Lasarge et al. (2009)