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. 2016 Mar 1;39(3):589–601. doi: 10.5665/sleep.5534

Figure 6.

Figure 6

Cortical expression of several genes is affected by the lack of REV-ERBα and sleep deprivation. Mean (1 SEM) levels of mRNA expression in the cortex of WT (n = 10) and KO (n = 9) mice, submitted to either a 6 h sleep deprivation from ZT0–6 (SDep, black bars) or allowed to sleep ad lib (control, white bars). Normalized expression levels (see Methods) are expressed relative to the WT control group (set to 1.0). Red stars indicate a significant effect of the sleep deprivation within genotypes (P < 0.05; post hoc t-tests), while blue stars indicate genotype differences (2-way ANOVA, factors genotype [‘G’] and sleep condition [‘SDep’]; Homer1a: ‘G’ P = 0.99, ‘SDep’ P < 0.001; Sgk1: ‘G’ P = 0.77, ‘SDep’ P < 0.001; Fabp7: ‘G’ P < 0.001; ‘SDep’ P = 0.98; Bmal1: ‘G’ P < 0.001, ‘SDep’ P = 0.42; Npas2: ‘G’ P = 0.004, ‘SDep’ P = 0.003; Clock: ‘G’ P = 0.02, ‘SDep’ P = 0.18; Dbp: ‘G’ < 0.001, ‘SDep’ P = 0.02, Per2: ‘G’ P = 0.06; ‘SDep’ P = 0.003; For none of the transcripts did the interaction term reach significance; ‘GxSDep’ P > 0.13).