Table 1.
Affymetrix microarray data of genes downregulated by NFI-C2 and upregulated by FoxF1
| Gene description | Gene symbol | Cancer association | Reference |
|---|---|---|---|
| ATP-binding cassette, sub-family G (WHITE), member 2 | Abcg2/Bcrp | Multi-drug resistance | [41, 42] |
| Coagulation factor II (thrombin) receptor | F2r/Par1 | Migration, invasion | [43] |
| Epithelial mitogen | Epgn | Proliferation, migration | [44, 45] |
| Fibronectin 1 | Fn1 | EMT | [46, 47] |
| GLI pathogenesis-related 2 | Glipr2 | EMT | [48] |
| Latent transforming growth factor beta binding protein 1 | Ltbp1 | EMT, invasion | [49, 50] |
| Lysyl oxidase | Lox | Migration, invasion | [17, 20] |
| Neurophilin 1 | Nrp1 | Migration, invasion, angiogenesis | [51, 52] |
| Platelet-derived growth factor, C polypeptid | Pdgfc | Angiogenesis, invasion | [53, 54] |
| Protease, serine, 23 | Prss23 | Proliferation | [55] |
| Rho GTPase activating protein 29 | Arhgap29 | Migration | [56] |
| Single stranded DNA binding protein 4 | Ssbp4 | Genomic stability | [57] |
| Thrombospondin | Thbs1 | Invasion | [58, 59] |
| Transforming growth factor, beta 2 | Tgfb2 | EMT, invasion | [60] |
| WAS/WASL interacting protein family, member 1 | Wipf1 | Migration, invasion | [61, 62] |
| Vestigial like 3 (Drosophila) | Vgll3 | Proliferation, migration | [63] |
| Vimentin | Vim | EMT | [64] |
Affymetrix microarrays were used to compare the transcriptome of HC11 wild type cells to that of cells overexpressing NFI-C2 or FoxF1. Associating this array with a previous array where the transcriptome of MDA-MB 436 cells overexpressing NFI-C2 or vector control, resulted in 17 genes downregulated by NFI-C2 in both arrays and upregulated by FoxF1 in the HC11 array