Table 5.

Results of Cox proportional hazards analysis after adjusting for modalities, xerostomia, mucositis, dermatitis, body weight loss, dysphagia, fistula formation, anemia, leucopenia and thrombocytopenia

	5-year OS			5-year LPFS
Adjusted factors	Hazard ratio (HR)	95 % CI	p value	Hazard ratio (HR)	95 % CI	p value
IGRT vs Non-IGRT	0.46	0.22–0.97	0.042	0.18	0.06–0.56	0.003
aXerostomia (Acute)	0.92	0.45–1.88	0.813	1.32	0.53–3.33	0.554
Mucositis	0.73	0.42–1.27	0.270	0.93	0.41–2.11	0.856
Dermatitis	1.05	0.68–1.63	0.821	0.60	0.32–1.11	0.103
Body weight loss	1.31	0.68–2.54	0.427	0.32	0.09–1.13	0.076
Dysphagia	0.93	0.60–1.45	0.762	0.56	0.27–1.19	0.122
Fistula formation or superficial cases of skin dehiscence	0.00	0.00–0.00	0.978	0.00	0.00–0.00	0.985
Anemia	2.57	1.16–5.67	0.020	5.83	2.22–15.31	0.000
Leucopenia	1.08	0.67–1.73	0.766	0.85	0.47–1.54	0.588
Thrombocytopenia	0.62	0.29–1.33	0.220	0.59	0.23–1.38	0.206

Abbreviations: CI confidence Interval, IGRT image-guided radiotherapy, LPFS local progression-free survival rate, OS overall survival rate

^aAcute xelostomia: Acute toxicity is defined as occurring < 90 days after beginning RT