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. 2016 Feb 22;16:134. doi: 10.1186/s12885-016-2185-5

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© Jayachandran et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Loss of TKTL1 expression changes cell cycle distribution of melanoma cells. Cell cycle phases were determined by propidium iodide staining of melanoma cells and subsequent flow cytometric analysis. A representative histogram of cell cycle analysis of LM-MEL-59 is shown after a control siRNA treatment and b TKTL1 siRNA treatment. Analysis of percentage of cells in e G0-G1 phase and S phase cell after treatment of LM-MEL-59 with TKTL1 or control siRNA. Values are ± SD of three experiments in triplicate (*, p < 0.05, **, p < 0.005). Histograms depicting distribution of cell cycle phase in LM-MEL-44 after treatment with c empty vector control and d TKTL1 pcDNA. Cell cycle distribution of f GO-G1 and S phase cell population after 48 h of ectopic expression of TKTL1 or empty vector in LM-MEL-44 was performed. Values are ± SD of three experiments in triplicate (*, p < 0.05, **, p < 0.005)