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. 2016 Feb 10;146(3):484–493. doi: 10.3945/jn.115.227561

FIGURE 4.

FIGURE 4

Prenatal choline supplementation partially normalized dysregulated genes in the hippocampus on PND65 of FID rats. (A) Scatter plot showing differentially expressed genes between the FID-C and FID groups. (B) Heat map showing gene clusters from all treatment groups. The key indicates differential gene expression by diet. Overlapped regions of Venn diagrams depict genes (127 downregulated and 181 upregulated) altered in the FID and normalized in the FID-C group. (C) Interactive gene networks implicated in the pathogenesis of Alzheimer disease, schizophrenia, autism, and mood disorders that were normalized by prenatal choline treatment of the FID group. CPM, counts per million; Down, downregulated; FC, fold change; FID, formerly iron deficient; FID-C, FID-choline; IS, iron sufficient; IS-C, IS choline; PND, postnatal day; Up, upregulated. A list of definitions of gene and protein names used in this figure is included in Supplemental Material.