FIGURE 5.

Prenatal choline supplementation reprogrammed the hippocampal transcriptome of PND65 IS-C rats. (A) Bar graphs showing functions that are associated with dysregulated genes in the transcriptome of IS-C rats. The key above the graph explains the number of altered genes and direction of change relative to IS rats. (B) Gene networks altered in the IS-C hippocampus that are implicated in the cognitive impairment and the pathogenesis of schizophrenia, major depression, and Alzheimer disease. Down, downregulated; IS, iron sufficient; IS-C, IS choline; PND, postnatal day; Up, upregulated. A list of definitions of gene and protein names used in this figure is included in Supplemental Material.