TABLE 3.
RRs (95% CIs) for the association between each 1-mmol/L increase in maternal fasting plasma glucose concentrations and offspring adiposity measures at birth and follow-up
Crude |
Model 11 |
Model 1 + birth weight2 |
|||||
n | RR (95% CI) | P value | RR (95% CI) | P value | RR (95% CI) | P value | |
Macrosomia (birth weight >4000 g) | 661 | 1.18 (1.05, 1.32) | 0.006 | 1.21 (1.07, 1.38) | 0.003 | NA3 | NA |
Large-for-gestational age | 661 | 1.18 (1.03, 1.34) | 0.016 | 1.19 (1.02, 1.39) | 0.026 | NA | NA |
Overweight/obesity at 5 mo4 | 405 | 1.07 (0.77, 1.48) | 0.697 | 1.18 (0.79, 1.78) | 0.417 | 1.07 (0.70, 1.65) | 0.755 |
Overweight/obesity at 12 mo4 | 397 | 1.04 (0.84, 1.28) | 0.724 | 1.09 (0.84, 1.40) | 0.514 | 1.03 (0.80, 1.33) | 0.824 |
Overweight/obesity at 7 y5 | 351 | 1.27 (1.07, 1.51) | 0.007 | 1.21 (1.01, 1.50) | 0.041 | 1.20 (1.01, 1.49) | 0.042 |
Adjusted for maternal age at index child's birth, parity, socioeconomic status, prepregnancy BMI, smoking during pregnancy, gestational age at oral-glucose-tolerance test, gestational weight gain, and gestational age at delivery. For multivariate analyses, the final sample sizes were 616, 381, 374, and 325 for ponderal index and BMI z scores at 5 mo, 12 mo, and 7 y, respectively, because of missing data on prepregnancy BMI, parity, and socioeconomic status.
Adjusted for covariates in model 1 and child’s birth weight.
NA, not applicable.
Defined as age- and sex-specific BMI-for-age z scores >85th percentile according to the WHO Child Growth Standards.
Defined as age- and sex-specific BMI-for-age z scores >2 SD according to the WHO growth reference.