TABLE 1.
Baseline characteristics of the study population, SU.VI.MAX cohort, France, 1994–20071
| Noncases (n = 7882) | Overall mortality (n = 207) | Mortality by CVD or cancer (n = 164) | Cancer-specific mortality (n = 123) | P value | |
| DII | 0.7 ± 1.92 | 0.8 ± 1.7 | 0.8 ± 1.7 | 0.8 ± 1.7 | 0.6 |
| Age, y | 48.9 ± 6.3 | 52.5 ± 5.4 | 53 ± 5.4 | 52.9 ± 5.4 | <0.0001 |
| Sex, n (%) | <0.0001 | ||||
| Male | 3209 (40.7) | 117 (56.5) | 89 (54.3) | 56 (45.5) | |
| Female | 4673 (59.3) | 90 (43.5) | 75 (45.7) | 67 (54.5) | |
| Intervention group, n (%) | 0.7 | ||||
| Antioxidants | 3951 (50.1) | 101 (58.8) | 79 (48.1) | 57 (46.3) | |
| Placebo | 3931 (49.9) | 106 (51.2) | 85 (51.8) | 66 (53.7) | |
| Educational level, n (%) | 0.1 | ||||
| Primary | 1575 (20.0) | 54 (26.1) | 42 (25.6) | 26 (21.6) | |
| Secondary | 2982 (37.8) | 73 (35.3) | 60 (36.6) | 48 (39.0) | |
| University | 3325 (42.2) | 80 (38.6) | 62 (37.8) | 49 (39.8) | |
| Smoking status, n (%) | 0.0003 | ||||
| Never smoker | 3809 (48.3) | 73 (33.2) | 58 (35.4) | 45 (36.6) | |
| Former smoker | 3031 (38.5) | 92 (44.4) | 72 (43.9) | 52 (42.3) | |
| Current smoker | 1042 (13.2) | 42 (20.3) | 34 (20.7) | 26 (21.1) | |
| Physical activity, n (%) | 0.04 | ||||
| Irregular | 1966 (24.9) | 36 (17.4) | 27 (16.5) | 20 (16.3) | |
| <1 h/d of walking or equivalent | 2374 (30.1) | 71 (34.3) | 58 (35.4) | 47 (38.2) | |
| ≥1 h/d of walking or equivalent | 3542 (44.9) | 100 (48.3) | 79 (48.2) | 56 (45.5) | |
| BMI, n (%) | 0.05 | ||||
| <25 kg/m2 | 5099 (64.7) | 118 (57.0) | 93 (56.7) | 76 (61.8) | |
| ≥25–30 kg/m2 | 2289 (29.0) | 70 (33.8) | 55 (33.5) | 35 (28.5) | |
| ≥30 kg/m2 | 494 (6.3) | 19 (9.2) | 16 (9.8) | 12 (9.8) | |
| 24-h Dietary records, n | 9.4 ± 3.4 | 9.6 ± 3.1 | 9.5 ± 3.1 | 9.5 ± 3.1 | 0.4 |
| Without alcohol energy intake, kcal/d | 1962 ± 551.3 | 1984.6 ± 563.5 | 1997.6 ± 547.9 | 1989.5 ± 565.8 | 0.6 |
| Alcohol intake, g/d | 18.1 ± 20.7 | 23.2 ± 23.4 | 23.9 ± 23.2 | 22.4 ± 22.0 | 0.002 |
| Family history of cancer3 | 2728 (34.6) | 69 (33.3) | 53 (32.3) | 38 (30.9) | 0.7 |
| Family history of CVD3 | 3190 (40.5) | 87 (42.0) | 66 (40.2) | 49 (39.8) | 0.6 |
1
P value for the comparison between noncases and all death causes, by Student's t test or χ2 test where appropriate. CVD, cardiovascular disease; DII, Dietary Inflammatory Index; SU.VI.MAX, Supplémentation en Vitamines et Minéraux Antioxydants.
2
Mean ± SD (all such values).
3
In first-degree relatives.