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. 2016 Feb 22;12(2):e1004735. doi: 10.1371/journal.pcbi.1004735

Fig 1. Computational model of βAR- and NMDAR-mediated cAMP signaling pathways.

Fig 1

A. Signaling pathways leading to cAMP production, and the downstream mechanisms involving PDE4. B. Morphology implemented for the computational model. Reflective boundary conditions occur at the membrane as well as cut surface of the soma and dendrite. The morphology is discretized with 0.9 μm voxels for the cytosol, with one layer of 0.3 μm submembrane voxels and one layer of 0.6 μm voxels adjacent to the submembrane voxels. C. Signaling pathways involved in Gs-Gi switching and GRK desensitization implemented in the model. p indicates a phosphorylation step.