. 2015 Jul 10;98(3):319–332. doi: 10.1189/jlb.4RI0115-006RR

TABLE 1.

Consequences of macrophage interactions in vivo

Macrophages visualized	Interacting cell	Consequence of contact	Location	Event-triggering contact	Time-point	Reference
F4/80⁺ Kupffer cells	CD49b⁺ platelets	Platelet encasement of bacteria and engulfment	Liver	B. cereus or MRSA infection	1–10 min postinfection	[57]
F4/80⁺ Kupffer cells	Antibody-coated B16F10 tumor cells	Phagocytosis and digestion	Liver	Tumor cells injected into antibody-treated mice	24 h after tumor cell injection	[63]
CX3CR1-GFP⁺ macrophages/microglia	Thy1-YFP⁺ axons	Axon dieback and phagocytosis	Spinal cord	Traumatic spinal-cord injury	5 and 22 d after injury	[77]
VSV⁺ SCS macrophages	VSV-specific B cells	Antigen transfer and B cell activation	Popliteal lymph node	VSV virus infection	5–30 min postinfection	[80]
Fluorescent dextran⁺ macrophages	OT-I CD8⁺ T cells (naïve)	Suboptimal CD8⁺ T cell activation	Inguinal lymph node	VV infection	6–8 h postinfection	[87]
CD11c-YFP⁺ SCS macrophages	OT-I CD8⁺ T cells (memory)	Parasite invasion of CD8⁺ T cells	Mesenteric lymph node	T. gondii infection	5 h postinfection	[88]
LysM-GFP⁺ Kupffer cells	OT-II CD4⁺ T cells (effector)	CD4⁺ T cell retention in the granuloma	Liver granulomas	M. bovis BCG infection	1–3 wk postinfection	[92]
Nanobead⁺ Kupffer cells	OT-I CD8⁺ T cells (effector)	Antigen presentation to CD8⁺ T cells	Liver granulomas	L. donovani infection	14–21 d postinfection	[93]
F4/80⁺ Kupffer cells	CXCR6-GFP iNKT cells	iNKT cell activation	Liver sinusoids	B. burgdorferi infection	24 h postinfection	[94]
CD11c-mCherry⁺ adipose tissue macrophages	OT-II CD4⁺ T cells (naïve)	CD4 T cell activation	Adipose tissue	OVA injection	2 h after injection	[100]
Fluorescent dextran⁺ macrophages	CX3CR1-GFP⁺ DCs	Unknown	Lung	Inhalation of B. anthracis spores	5 h postinfection	[103]
Fluorescent dextran⁺ macrophages	MBP-specific CD4⁺ T cells (effectors)	Antigen presentation and activation of CD4⁺ T cells	Spinal-cord meninges	Intravenous injection of 5 × 10⁶ MBP-specific CD4⁺ T cells	2.5 d posttransfer	[113]
Fluorescent dextran⁺ macrophages	Tumor cells	Comigration	Mammary tumors	Injection of MTLn3 carcinoma cells	3 wk after injection	[124]
Dextran⁺, LysM-GFP⁺, or c-fms-GFP⁺ macrophages	Tumor cells	Intravasation	Mammary tumors	Spontaneous carcinoma	16- to 18-wk-old mice	[118]

YFP, Yellow fluorescent protein; OT-I, OVA -specific CD8⁺ TCR transgenic cells; OT-II, OVA-specific CD4⁺ TCR transgenic cells.