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. Author manuscript; available in PMC: 2016 Feb 23.
Published in final edited form as: Life Sci. 2015 Jan 14;123:61–71. doi: 10.1016/j.lfs.2014.12.024

Figure 4. Ito kinetics are altered in chronic HF.

Figure 4

A. Representative steady state inactivation traces of Ito recorded with the voltage protocol displayed in the inset. B. Steady state inactivation and activation curves of Ito fit to Boltzmann functions, demonstrates a “window” current, that is reduced as the heart fails C. Representative traces elicited by two-step protocol in control and 4 M HF; voltage protocol in inset. D. Summary data of recovery from inactivation; HF significantly prolongs recovery to 50% of total Ito current (p<0.05 vs control).