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. Author manuscript; available in PMC: 2016 Feb 23.
Published in final edited form as: Small. 2015 Oct 30;11(47):6347–6357. doi: 10.1002/smll.201502202

Figure 1. Design, fabrication, and preclinical efficacy of rare earth nanoprobes.

Figure 1

ReANCs were synthesized by controlled coacervation of albumin monomers in solution and REs dissolved in a solvent. (A) AMD3100 was adsorbed onto the surface of fully formed ReANCs to generate AMD3100 functionalized ReANCs, or fReANCs. (B) Athymic nude mice were inoculated with human breast cancer cells through the tail vein. Animals were treated with either ReANCs or fReANCs and SWIR imaging performed to determine nanoprobe-tumor localization. fReANCS were imaged in tumors up to 1 cm into the animal (B). Microlesions as small as 18 mm3 were detected with targeted probes (C). Probe localization to receptor positive tumors enabled optical molecular phenotyping (D).