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Effects of Mn2+ on drug-induced DNA cleavage mediated by WT and mutant M. tuberculosis gyrase. Results are shown for cleavage mediated by WT (black), GyrAA90S (A90S, blue), and GyrAA90V (A90V, red) in the presence of ciprofloxacin. Assays included 2.5 mM Mn2+, the concentration that yielded maximal enzyme activity, instead of Mg2+. Error bars represent the SD of at least three independent experiments.
