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. 2016 Feb 1;113(7):E932–E941. doi: 10.1073/pnas.1517181113

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Fig. 5. — ACh (0.3 μM) effect on heart rate and AV conduction in isolated Langendorff-perfused hearts. (A) Representative traces in CTRL conditions (Top) and ACh-perfused (Bottom) hearts from WT, Ca_v1.3^−/−, Ca_v1.3^−/−/Girk4^−/−, and Girk4^−/− mice. (B) Mean value of heart rate in control (Left; n = 13 WT, n = 8 Ca_v1.3^−/−, n = 7 Ca_v1.3^−/−/Girk4^−/−, and n = 16 Girk4^−/− hearts) and ACh-perfused (Middle; n = 12 WT, n = 9 Ca_v1.3^−/−, n = 7 Ca_v1.3^−/−/Girk4^−/−, and n = 16 Girk4^−/− hearts) hearts. (Right) ACh-dependent heart rate reduction expressed as percentage measured in the different mouse strains studied. (C) Mean value of PR interval in Tyrode’s solution (n = 9 WT, n = 9 Ca_v1.3^−/−, n = 8 Ca_v1.3^−/−/Girk4^−/−, and n = 10 Girk4^−/− hearts; Left) and ACh (n = 9 WT, n = 9 Ca_v1.3^−/−, n = 8 Ca_v1.3^−/−/Girk4^−/−, and n = 8 Girk4^−/− hearts; Middle) perfused hearts. (Right) ACh-dependent PR interval reduction expressed as percentage. Statistics: one-way ANOVA followed by Tukey’s multiple comparisons test. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.