To display this association, 3 hypothetical average participants with their estimated rate of cognitive decline based on the complete model with all the cases analyzed in this study are illustrated. Model derived trajectories of cognitive decline for 3 participants with low (red, 10th percentile), average (black, 50th percentile) and high (blue, 90th percentile) brain BDNF expression levels in the dorsal lateral prefrontal cortex. BDNF = brain-derived neurotrophic factor.