Figure 1.

Supraphysiologic αTOC levels in brain exacerbates ischemic stroke-induced lesion. A) Representative phenotype of 10-wk-old TTP-deficient mouse (KO) compared with WT and HT siblings; bar = 1 cm. B) Brain αTOC levels of TTP WT (n = 7), HT (n = 12), and KO (n = 5) mice (*P < 0.01 KO vs. WT, ^†P < 0.05 KO vs. HT). C) Representative T2-weighted MRI slice of WT, HT, and KO mice at 48 h after MCAO; bar = 5 mm. D) TTP KO mice had significantly smaller stroke-induced lesion volume at 48 h compared with WT controls. Data are mean ± sd percent lesion volume vs. WT (*P < 0.01 vs. WT).