Table 1.

Ceramide major species in healthy corneas and diabetics (n>=3 per group).

Major Cer species were identified and quantified in human cadaver corneas from Healthy, T1DM, and T2DM donors. In healthy donors, C16:0 species were the highest followed by C24:0, C24:1, and C22:0. In T1DM, C16:0 species were also the highest followed by C18:0, C24:0, and C22:0. In T2DM, C16:0 was highest, C18:0 was second highest, followed by C24:0, and C24:1. At least three different samples from three different donors were used (n>=3).

Ceramides Species	Healthy (pmol/mg tissue)	T1DM (pmol/mg tissue)	T2DM (pmol/mg tissue)
C14:0	0.08±0.01	0.12±0.02	0.13±0.02
C16:0	1.45±0.23	3.76±0.49	3.06±0.36
C18:1	0.11±0.03	0.65±0.14	1.10±0.26
C18:0	0.59±0.15	2.17±0.33	2.95±0.42
C20:0	0.38±0.10	0.89±0.11	1.16±0.20
C22:0	0.72±0.14	1.10±0.16	1.28±0.24
C24:1	0.88±0.14	0.86±0.14	1.49±0.29
C24:0	0.95±0.14	1.36±0.18	1.58±0.24
C26:1	0.11±0.03	0.05±0.01	0.08±0.02
C26:0	0.01±0.00	0.14±0.02	0.10±0.02